Scientific Publications
Long-term observations of macular thickness after subretinal implantation of a photovoltaic prosthesis in patients with atrophic age-related macular degeneration
Mahiul M K Muqit7,1,2, Yannick Le Mer3, Frank G Holz4 and José A Sahel3,5,6 Published 14 October 2022 • © 2022 IOP Publishing Ltd Journal of Neural Engineering, Volume 19, Number 5 Citation Mahiul M K Muqit et al 2022 J. Neural Eng. 19 055011DOI 10.1088/1741-2552/ac9645 Abstract Objective. Subretinal prostheses electrically stimulate the residual inner retinal neurons to partially restore vision. We investigated the
Simultaneous perception of prosthetic and natural vision in AMD patients
Abstract Loss of photoreceptors in atrophic age-related macular degeneration (AMD) results in severe visual impairment. Since the low-resolution peripheral vision is retained in such conditions, restoration of central vision should not jeopardize the surrounding healthy retina and allow for simultaneous use of the natural and prosthetic sight. This
Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration
Implantation of the PRIMA did not decrease the residual natural acuity, and it restored visual sensitivity in the former scotoma in each of the 5 patients. In 3 patients with the proper placement of the chip, prosthetic visual acuity was only 10% to 30% less than the level
Restoration of sight in geographic atrophy using a photovoltaic subretinal prosthesis
OBJECTIVE: To evaluate feasibility of restoration of central vision in patients with age-related macular degeneration using a wireless photovoltaic subretinal implant. In particular, to assess safety of sub-retinal implantation and quality of prosthetic vision in patients with geographic atrophy. CONCLUSIONS: Wireless chip PRIMA can be safely implanted under the atrophic
Physics Today : Restoring sight with retinal prostheses
By implanting electrodes that transmit visual information to the surviving neurons in a diseased retina, it's possible to bring the eye's dormant neural circuitry back to life. Daniel Palanker and Georges GoetzPhysics Today : 71, 7, 26 (2018); https://doi.org/10.1063/PT.3.3970 Read more »
Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons
According to computational model, pillars having a cathodic return electrode above the INL and active anodic ring electrode at the surface of the implant would enable lower stimulation threshold, compared to planar arrays with circumferential return, but suffer from greater cross-talk between the neighboring pixels. Significance. 3D electrodes in subretinal prostheses
Photovoltaic restoration of sight in rodents with retinal degeneration
Photovoltaic restoration of sight in rodents with retinal degeneration (Conference Presentation)Daniel V. Palanker Stanford Univ. (United States)Proc. SPIE 10052, Optogenetics and Optical Manipulation, 100520I (April 19, 2017); doi:10.1117/12.2250427; http://dx.doi.org/10.1117/12.2250427 Read more »
Deafferented adult rod bipolar cells create new synapses with photoreceptors to restore vision
Loss of photoreceptors during retinal degeneration results in permanent visual impairment. Strategies for vision restoration based on the reintroduction of photoreceptors inherently rely on the ability of the remaining retinal neurons to correctly synapse with new photoreceptors. We show that deafferented bipolar cells in the adult mammalian retina can reconnect
ARTIFICIAL VISION : Pixium Vision: First Clinical Results and Innovative Developments
Pixium Vision and its partners are developing two VRS solutions for blind patients: an epi-retinal and a sub-retinal approach. This chapter describes the specificities of the epi-retinal IRIS® VRS that has obtained the European CE mark cerfication, and also discuss the associatedinnovations developed at the Vision Institute for future VRS models.
ATIS – Event-Based Tone Mapping for Asynchronous Time-Based Image Sensor
The asynchronous time-based neuromorphic image sensor ATIS is an array of autonomously operating pixels able to encode luminance information with an exceptionally high dynamic range (>143 dB). This paper introduces an event-based methodology to display data from this type of event-based imagers, taking into account the large dynamic range and
SiC protective coating for photovoltaic retinal prosthesis
SiC coatings demonstrating no erosion in accelerated aging test for 112 d at 87 °C, equivalent to about 10 years in vivo, can offer effective protection of the implants. Photovoltaic retinal prostheses with plasma-enhanced, chemically vapor deposited (PECVD) amorphous silicon carbide (SiC:H) SiC coatings exhibited effective protection from erosion during
Optimization of return electrodes in neurostimulating arrays
Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.Thomas Flores, Georges Goetz, Xin